fats to fuel

A public protein engineering initiative

As part of an NSF CAREER grant on the mechanism of alkene synthesis from fatty acids catalyzed by OleT, we are seeking public participation in an ongoing protein design experiment.  We have characterized several catalysts that are able to generate hydrocarbons, albeit with highly variable efficiencies.  Using one of these enzymes (CYP-MP) as a scaffold, which is also the poorest alkene producer that we know of, we are asking the public to design mutants of CYP-MP which we will generate, test, and publish the results online.