non-ribosomal peptides

Many pharmaceuticals deployed in the clinic (ex. antibiotics and cytostatics) derive from natural products that are assembled in an iterative fashion by non-ribosomal peptide synthetases (NRPS) and accessory tailoring enzymes.  We are interested in understanding the remarkable diversity of non-ribosomal peptide tailoring reactions andthe molecular basis for enzyme:NRPS interactions in efforts to leverage these catalysts for the development of combinatorial libraries of new natural products.